Hemophilia B symptoms

Dive into the details of hemophilia B signs and symptoms, which can all vary depending on the individual.

MY HOME Hemphilia B Symptoms

Signs and symptoms of hemophilia B

People living with hemophilia B bleed longer than other people due to deficiencies with factor IX.1

The frequency of bleeding episodes depends on the level of factor IX clotting activity.1

Bleeding episodes may occur more often in childhood and adolescence than in adulthood. This can be due to greater physical activity levels during those stages of life, and also to more vulnerability during rapid growth periods.2

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Hemophilia B symptoms may include3:

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Bleeding of the mouth and gums, including severe bleeding after losing a tooth

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Frequent, often hard-to-control nosebleeds

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Bleeding into the joints (knees, elbows, and ankles) causing swelling, pain, or tightness

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Bleeding after male circumcision (removal of the foreskin of the penis)

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Bleeding after receiving injections, including vaccinations

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Bleeding in the head of a newborn after a difficult delivery

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Blood in the stool or urine

Mild, moderate, or severe hemophilia B

A person can have mild, moderate, or severe hemophilia B. The severity level of hemophilia B depends on how much working clotting factor IX is in the blood.1

Severity Symptoms Without Treatment
Mild hemophilia B:
6% to 49% factor IX level 		Bleeding only after serious trauma, injury, surgery
First episode may not occur until adulthood
Women may experience heavy menstrual bleeding; hemorrhage during childbirth
Moderate hemophilia B:
1% to 5% factor IX level 		Bleeding after injuries or trauma
Severe hemophilia B:
Less than 1% factor IX level 		Bleeding after injuries, as well as spontaneously, with no obvious cause (often into muscles and joints)

When considering the levels of severity, keep in mind that individual bleeding patterns vary. In some cases, people with severe hemophilia may not have frequent bleeding or spontaneous bleeds, while others with moderate hemophilia may have more bleeding than expected.4

Speak to your healthcare provider to understand more about bleeding patterns and severity.

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  1. National Hemophilia Foundation. Hemophilia B. https://www.hemophilia.org/bleeding-disorders-a-z/types/hemophilia-b. Accessed February 13, 2023.
  2. Konkle BA, Nakaya Fletcher S. Hemophilia B. In: Adam MP, Everman DB, Mirzaa GM, et al., eds. GeneReviews®. Seattle (WA): University of Washington, Seattle; October 2, 2000. https://www.ncbi.nlm.nih.gov/books/NBK1495/. Accessed February 13, 2023.
  3. Centers for Disease Control and Prevention. What is hemophilia? https://www.cdc.gov/ncbddd/hemophilia/facts.html. Accessed February 13, 2023.
  4. Hemophilia of Georgia. Severity levels. von Willebrand Disease & Platelet Disorders Handbook. 2023. https://www.hog.org/handbook. Accessed February 13, 2023.